MCAT Organic Chemistry Question 127: Answer and Explanation
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Question: 127
7. Which of the following would react most readily with a carboxylic acid to form an amide?
- A. Methylamine
- B. Triethylamine
- C. Diphenylamine
- D. Ethylmethylamine
Correct Answer: A
Explanation:
Methylamine would react readily to form an amide. The less substituted the nucleophile, the easier it will be for the nucleophile to attack the carbonyl carbon and form the amine. In fact, triethylamine choice (B), would not be able to form an amide at all because it does not have a hydrogen to lose while attaching to the carbonyl carbon.