MCAT Biology Question 123: Answer and Explanation

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Question: 123

3. In an experiment, enteropeptidase secretion was blocked. As a direct result, levels of all of the following active enzymes would likely be affected EXCEPT:

  • A. trypsin.
  • B. aminopeptidase.
  • C. chymotrypsin.
  • D. carboxypeptidase A.

Correct Answer: B

Explanation:

Aminopeptidase is a brush-border peptidase secreted by the cells lining the duodenum; it does not require enteropeptidase for activation. Both trypsinogen and procarboxypeptidases A and B are activated by enteropeptidase, eliminating choices (A) and (D). Once activated, trypsin can activate chymotrypsinogen; if trypsinogen cannot be activated, then chymotrypsinogen will not be activated either, eliminating choice (C).

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