MCAT Biology Question 113: Answer and Explanation
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Question: 113
8. Where are most self-reactive T-cells eliminated?
- A. Spleen
- B. Lymph nodes
- C. Bone marrow
- D. Thymus
Correct Answer: D
Explanation:
T-cells mature in the thymus, where they are "educated." This education involves the elimination of T-cells with improper binding to MHC–antigen complexes (positive selection) and self-reactive T-cells (negative selection). Thus, self-reactive T-cells are eliminated in the thymus.