GRE Reading Comprehension

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Warm-blooded animals have elaborate physiological controls to maintain constant body temperature (in humans, 37°C). Why then during sickness should temperature rise, apparently increasing stress on the infected organism? It has long been known that the level of serum iron in animals falls during infection. Garibaldi first suggested a relationship between fever and iron. He found that microbial synthesis of siderophores-substances that bind iron-in bacteria of the genus Salmonella declined at environmental temperatures above 37°C and stopped at 40.3°C. Thus, fever would make it more difficult for an infecting bacterium to acquire iron and thus to multiply. Cold—blooded animals were used to test this hypothesis because their body temperature can be controlled in the laboratory. Kluger reported that of iguanas infected with the potentially lethal bacterium A. hydrophilia, more survived at temperatures of 42°C than at 37°C, even though healthy animals prefer the lower temperature. When animals at 42°C were injected with an iron solution, however, mortality rates increased significantly. Research to determine whether similar phenomena occur in warm-blooded animals is sorely needed.

Question List: 1 2 3

If it were to be determined that "similar phenomena occur in warm-blooded animals" (lines 15-16), which of the following, assuming each is possible, is likely to be the most effective treatment for warm-blooded animals with bacterial infections?

  • A Administering a medication that lowers the animals' body temperature
  • B Injecting the animals with an iron solution
  • C Administering a medication that makes serum iron unavailable to bacteria
  • D Providing the animals with reduced-iron diets
  • E Keeping the animals in an environment with temperatures higher than 37 °C

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