GRE Reading Comprehension

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Warm-blooded animals have elaborate physiological controls to maintain constant body temperature (in humans, 37°C). Why then during sickness should temperature rise, apparently increasing stress on the infected organism? It has long been known that the level of serum iron in animals falls during infection. Garibaldi first suggested a relationship between fever and iron. He found that microbial synthesis of siderophores-substances that bind iron-in bacteria of the genus Salmonella declined at environmental temperatures above 37°C and stopped at 40.3°C. Thus, fever would make it more difficult for an infecting bacterium to acquire iron and thus to multiply. Cold—blooded animals were used to test this hypothesis because their body temperature can be controlled in the laboratory. Kluger reported that of iguanas infected with the potentially lethal bacterium A. hydrophilia, more survived at temperatures of 42°C than at 37°C, even though healthy animals prefer the lower temperature. When animals at 42°C were injected with an iron solution, however, mortality rates increased significantly. Research to determine whether similar phenomena occur in warm-blooded animals is sorely needed.

Question List: 1 2 3

Which of the following can be inferred about warm-blooded animals solely on the basis of information in the passage?

  • A The body temperatures of warm-blooded animals cannot be easily controlled in the laboratory.
  • B Warm-blooded animals require more iron in periods of stress than they do at other times.
  • C Warm-blooded animals are more comfortable at an environmental temperature of 37°C than they are at a temperature of 42°C.
  • D In warm-blooded animals, bacteria are responsible for the production of siderophores, which, in turn, make iron available to the animal.
  • E In warm-blooded animals, infections that lead to fever are usually traceable to bacteria.

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