GRE Text Completion Question 1230

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Natural selection tends to eliminate genes that cause inherited diseases, acting most strongly against the most severe diseases; consequently, hereditary diseases that are (i) _____ would be expected to be very (ii) _____, but, surprisingly, they are not.

Blank(i)Blank(ii)
A lethal D perplexing
B untreated E refractory
C widespread F rare

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