MCAT Biology Question 18: Answer and Explanation
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Question: 18
3. Some studies suggest that in patients with Alzheimer's disease, there is a defect in the way the spindle apparatus attaches to the kinetochore fibers. At which stage of mitotic division would one first expect to be able to visualize this problem?
- A. Prophase
- B. Metaphase
- C. Anaphase
- D. Telophase
Correct Answer: A
Explanation:
The spindle apparatus first interacts with the kinetochore fibers near the end of prophase. While the spindle apparatus aligns the chromosomes at the equatorial plate during metaphase, choice (B), the initial connection of the microtubule to the kinetochore occurs in prophase.