MCAT Biochemistry Question 99: Answer and Explanation
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Question: 99
9. Which of the following RNA molecules or proteins is NOT found in the spliceosome during intron excision?
- A. snRNA
- B. hnRNA
- C. shRNA
- D. snRNPs
Correct Answer: C
Explanation:
shRNA (short hairpin RNA) is a useful biotechnology tool used in RNA interference. It is not, however, produced in the nucleus for use in the spliceosome. It targets mRNA to be degraded in the cytoplasm; it is not utilized in splicing of the hnRNA (heterogeneous nuclear RNA). snRNA (small nuclear RNA) and snRNPs (small nuclear ribonucleoproteins), however, do bind to the hnRNA to induce splicing.