MCAT Biochemistry Question 81: Answer and Explanation
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Question: 81
6. Which of the following enzymes is NOT involved in DNA replication?
- A. Primase
- B. DNA ligase
- C. RNA polymerase
- D. Telomerase
Correct Answer: C
Explanation:
During DNA replication, the strands are prepared by topoisomerases to relieve torsional strain. At the replication fork, primase, choice (A), creates a primer for the initiation of replication, which is followed by DNA polymerase. On the lagging strand, Okazaki fragments form which are joined by DNA ligase, choice (C). After the chromosome has been processed, the ends, called telomeres, are replicated with the assistance of the enzyme telomerase, choice (D). RNA polymerase, distinct from primase, is responsible for transcription.