MCAT Biochemistry Question 175: Answer and Explanation

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Test Information

Question: 175

10. Glucocorticoids have been implicated in stress-related weight gain because:

  • A. they increase appetite and decrease satiety signals.
  • B. they increase the activity of catabolic hormones.
  • C. they increase glucose levels, which causes insulin secretion.
  • D. they interfere with activity of the leptin receptor.

Correct Answer: C

Explanation:

Short-term glucocorticoid exposure causes a release of glucose and the hydrolysis of fats from adipocytes. However, if this glucose is not used for metabolism, it causes an increase in glucose level which promotes fat storage. The net result is the release of glucose from the liver to be converted into lipids in the adipose tissue under insulin stimulation.

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