MCAT Biochemistry Question 162: Answer and Explanation

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Question: 162

12. 2,4-dienoyl-CoA reductase is used in the oxidation of:

  • A. saturated fatty acids.
  • B. monounsaturated fatty acids.
  • C. polyunsaturated fatty acids.
  • D. cholesterol.

Correct Answer: C

Explanation:

In order for the enzymes of fatty acid oxidation to operate, there can be, at most, one double bond in the area of enzyme activity, and it must be oriented between carbons 2 and 3. In order to accomplish this in monounsaturated fatty acids, an isomerase is employed. When there are multiple double bonds that fall within the enzymatic binding site, both an isomerase and 2,4-dienoyl-CoA reductase are required for the oxidative enzymes to act on the fatty acid.

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