MCAT Biochemistry Question 148: Answer and Explanation
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Question: 148
13. In high doses, aspirin functions as a mitochondrial uncoupler. How would this affect glycogen stores?
- A. It causes depletion of glycogen stores.
- B. It has no effect on glycogen stores.
- C. It promotes additional storage of glucose as glycogen.
- D. Its effect on glycogen stores varies from cell to cell.
Correct Answer: A
Explanation:
Uncouplers inhibit ATP synthesis without affecting the electron transport chain. Because the body must burn more fuel to maintain the proton-motive force, glycogen stores will be mobilized to feed into glycolysis, then the TCA, and finally oxidative phosphorylation.