MCAT Biochemistry Question 123: Answer and Explanation
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Question: 123
3. When insulin is released, it acts to increase the absorption of glucose into skeletal muscle predominantly through which of the following transporters?
- A. GLUT 1
- B. GLUT 2
- C. GLUT 3
- D. GLUT 4
Correct Answer: D
Explanation:
GLUT is an abbreviation for glucose transporter and describes a family of sugar transporters with varying distributions and activities. GLUT 4 is found in adipose tissue and muscle, and mediates insulin-stimulated glucose uptake; in fact, it is the only insulin-responsive glucose transporter. Insulin acts via its receptor to translocate GLUT 4 to the plasma membrane. GLUT 4 in skeletal and cardiac muscle is also stimulated by exercise through an insulin-independent pathway.